Description

6-Chloro-2,3-Difluorobenzotrifluoride is a high-value fluorinated aromatic building block, essential for introducing the trifluoromethyl and halogenated phenyl motifs into advanced molecular architectures. Its precise structure enables the fine-tuning of electronic properties, lipophilicity, and metabolic stability in target compounds. This intermediate is critically needed by R&D and production teams in the pharmaceutical and agrochemical sectors for developing new active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides and fungicides, where the CF3 group enhances biological activity and environmental persistence.
• Liquid Crystal Materials: Serves as a core component in the synthesis of fluorinated liquid crystals for high-performance displays.
• Organic Electronics: Building block for electron-transport materials and semiconductors in OLEDs and organic photovoltaics.
• Polymer Modification: Imparts unique properties like chemical resistance and low surface energy when incorporated into specialty polymers.
• Cross-Coupling Reactions: A versatile substrate for Suzuki, Buchwald-Hartwig, and other palladium-catalyzed coupling reactions to create complex biaryl systems.

Basic Information

Product Name	6-Chloro-2,3-Difluorobenzotrifluoride
CAS No.	1208076-15-6
Molecular Formula	C7H2ClF5
Molecular Weight	216.54 g/mol
Synonyms	2,3-Difluoro-6-chlorobenzotrifluoride; 1-Chloro-2,3-difluoro-4-(trifluoromethyl)benzene; 6-Chloro-2,3-bis(fluoranyl)-1-(trifluoromethyl)benzene; 2,3-Difluoro-6-chloro-α,α,α-trifluorotoluene; Benzene, 1-chloro-2,3-difluoro-4-(trifluoromethyl)-; 6-Chloro-2,3-difluoro-α,α,α-trifluorotoluene
EINECS	Contact for details

Quality Control

Our 6-Chloro-2,3-Difluorobenzotrifluoride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC/HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.