Description

5-Chloro-1,3-Difluoro-2-Iodobenzene is a high-purity, multi-halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique substitution pattern makes it a critical intermediate for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for researchers and manufacturers developing active pharmaceutical ingredients (APIs), liquid crystal materials, and specialty agrochemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, especially in fluorinated and iodinated active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides where the halogen pattern confers specific biological activity.
• Material Science: Serves as a building block for organic electronic materials, including liquid crystals and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Sonogashira) to create complex biaryl structures.
• Chemical Research & Development: A versatile reagent for exploring new synthetic methodologies and creating compound libraries for screening.
• Ligand and Catalyst Preparation: Used in the synthesis of specialized ligands and organocatalysts for asymmetric synthesis.

Basic Information

Product Name	5-Chloro-1,3-Difluoro-2-Iodobenzene
CAS No.	1208076-02-1
Molecular Formula	C6H2ClF2I
Molecular Weight	274.44 g/mol
Synonyms	1-Chloro-3,5-difluoro-2-iodobenzene; 2-Iodo-1-chloro-3,5-difluorobenzene; 2-Iodo-5-chloro-1,3-difluorobenzene; Benzene, 5-chloro-1,3-difluoro-2-iodo-; 5-Chloro-1,3-difluoro-2-iodobenzene; 1208076-02-1
EINECS	Contact for details

Quality Control

Our 5-Chloro-1,3-Difluoro-2-Iodobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment ensures material consistency and reliability for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Recommended storage temperature is between 2°C and 8°C for long-term stability. Keep away from heat and incompatible materials. The container should be kept tightly sealed in a dry environment to prevent moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.