Description

2-Bromo-3,6-Difluorotoluene is a high-purity halogenated aromatic building block of significant importance in advanced organic synthesis. Its value lies in its unique substitution pattern, which allows for selective functionalization and the construction of complex molecular architectures. This compound is primarily needed by research and development chemists and process scale-up teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing difluorophenyl and bromoaryl motifs for drug discovery and development.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and pesticides, where the fluorine and bromine atoms contribute to biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions such as Suzuki, Stille, and Buchwald-Hartwig amination, enabling carbon-carbon and carbon-heteroatom bond formation.
• Fluorine Chemistry Studies: Utilized in academic and industrial research to explore the effects of fluorine substitution on aromatic systems and reaction pathways.
• Ligand and Catalyst Development: Employed in the synthesis of novel phosphine or N-heterocyclic carbene (NHC) ligands for asymmetric catalysis.

Basic Information

Item	Detail
Product Name	2-Bromo-3,6-Difluorotoluene
CAS No.	1208074-75-2
Molecular Formula	C7H5BrF2
Molecular Weight	207.02 g/mol
Synonyms	1-Bromo-2,5-difluoro-3-methylbenzene; 3-Methyl-2,5-difluorobromobenzene; 2,5-Difluoro-3-methylbromobenzene; 2-Bromo-3,6-difluoro-1-methylbenzene; Toluene, 2-bromo-3,6-difluoro-; 2-Bromo-3,6-difluoromethylbenzene
EINECS	Contact for details

Quality Control

Our 2-Bromo-3,6-Difluorotoluene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistent lot-to-lot performance. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided and available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.