Description

4-Fluoro-3-(trifluoromethyl)pyridine is a high-value fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both fluorine and a trifluoromethyl group on the pyridine ring, imparts significant electronic and steric properties that are highly sought after in modern chemical research and development. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the fluorine motif for improved efficacy and environmental profile.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and electronic materials requiring specific fluorinated aromatic units.
• Chemical Biology Probes: Utilized as a building block for fluorinated analogs of bioactive molecules to study metabolic pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects and scale-up services for specialized chemical entities.

Basic Information

Product Name	4-Fluoro-3-(trifluoromethyl)pyridine
CAS No.	1207670-92-5
Molecular Formula	C6H3F4N
Molecular Weight	165.09 g/mol
Synonyms	3-(Trifluoromethyl)-4-fluoropyridine; 4-Fluoro-3-trifluoromethylpyridine; 4-Fluoro-α,α,α-trifluoro-3-pyridinemethanol (precursor-related); Pyridine, 4-fluoro-3-(trifluoromethyl)-; 1207670-92-5; 4-F-3-CF3-Pyridine
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for our fluorinated heterocyclic compounds. Production follows cGMP principles where applicable, and every batch is analyzed to ensure it meets the high-purity standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.