Description

6-Fluoro-1H-Pyrazolo[4,3-B]Pyridin-3-Amine is a high-purity, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters because its unique fused pyrazolopyridine scaffold, functionalized with both fluorine and amine groups, provides a versatile platform for creating novel molecular architectures with targeted biological activity. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and drug discovery programs.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel small molecule drug candidates, particularly kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) due to its privileged heterocyclic core.
• Agrochemical Development: Serves as a precursor in the research and synthesis of new active ingredients for crop protection products.
• Chemical Biology Probes: Utilized in the development of fluorescent tags or affinity probes for studying biological pathways and target engagement.
• Material Science Precursor: Potential use in the synthesis of organic electronic materials or metal-organic frameworks (MOFs) due to its nitrogen-rich, planar structure.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or research-grade conditions.

Basic Information

Product Name	6-Fluoro-1H-Pyrazolo[4,3-B]Pyridin-3-Amine
CAS No.	1207530-00-4
Molecular Formula	C6H5FN4
Molecular Weight	152.13 g/mol
Synonyms	6-Fluoro-1H-pyrazolo[4,3-b]pyridin-3-amine; 3-Amino-6-fluoro-1H-pyrazolo[4,3-b]pyridine; 6-Fluoro-3-amino-1H-pyrazolo[4,3-b]pyridine; 6-Fluoro-1H-pyrazolo[4,3-b]pyridin-3-ylamine; 1207530-00-4; 6-Fluoro-1H-pyrazolo[4,3-b]pyridin-3-amine; 6-Fluoro-1H-pyrazolo[4,3-b]pyridin-3-amine (CAS 1207530-00-4)
EINECS	Contact for details

Quality Control

Our 6-Fluoro-1H-Pyrazolo[4,3-B]Pyridin-3-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and MS, to ensure compliance with research and development standards. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.