Description

Rac-Trans 3’-Hydroxymethylnicotine Hemisuccinate is a high-purity synthetic intermediate of significant interest in advanced pharmaceutical research and development. This compound is valued for its role as a key building block in the synthesis of novel nicotinic receptor ligands and other bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in neuroscience, medicinal chemistry, and the development of smoking cessation aids or neurological therapeutics.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel nicotinic acetylcholine receptor (nAChR) modulators and other targeted therapeutic agents.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies in drug discovery programs focused on the central nervous system.
• Reference Standard: Used as an analytical standard in method development and quality control for related pharmaceutical compounds and metabolites.
• Biochemical Research: Employed in studies investigating the binding mechanisms and metabolic pathways of nicotine and its analogs.
• Process Development: Utilized in the scale-up and optimization of synthetic routes for complex alkaloid-derived active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Rac-Trans 3’-Hydroxymethylnicotine Hemisuccinate
CAS No.	1207282-59-4
Molecular Formula	C16H22N2O5
Molecular Weight	322.36 g/mol
Synonyms	3'-Hydroxymethylnicotine Hemisuccinate (racemic trans); (Rac)-trans-3'-(Hydroxymethyl)nicotine Hemisuccinate; 1-Methyl-2-(3-pyridyl)pyrrolidine-3-methanol hemisuccinate; Nicotine Derivative Hemisuccinate; trans-3'-Hydroxymethylnicotine Hydrogen Succinate; Hemisuccinic acid salt of 3'-hydroxymethylnicotine; 3-Pyridinemethanol, 1-methyl-2-(3-pyridinyl)-3-pyrrolidinyl-, (2R,3S)-rel-, 4-hydroxy-4-oxobutanoate (1:1)
EINECS	Contact for details

Quality Control

Our Rac-Trans 3’-Hydroxymethylnicotine Hemisuccinate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Custom purity grades and analytical packages are available to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.