Description

2-Bromo-4-(Difluoromethoxy)Pyridine is a high-purity, halogenated pyridine derivative serving as a critical building block in advanced organic synthesis. This compound is valued for its unique molecular structure, which introduces both bromine and difluoromethoxy functional groups to enable precise chemical modifications. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the creation of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the production of advanced crop protection agents, where the difluoromethoxy and bromo groups contribute to biological activity and metabolic stability.
• Material Science Research: Employed in the synthesis of specialized ligands, functionalized polymers, and liquid crystal materials for electronic applications.
• Cross-Coupling Reactions: Serves as a versatile substrate in palladium-catalyzed reactions such as Suzuki, Stille, and Buchwald-Hartwig aminations for constructing complex biaryl systems.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological systems and diagnostic applications.

Basic Information

Product Name	2-Bromo-4-(Difluoromethoxy)Pyridine
CAS No.	1206984-48-6
Molecular Formula	C6H4BrF2NO
Molecular Weight	224.00 g/mol
Synonyms	4-(Difluoromethoxy)-2-bromopyridine; 2-Bromo-4-(difluoromethoxy)pyridine; Pyridine, 2-bromo-4-(difluoromethoxy)-; 2-Bromo-4-difluoromethoxypyridine
EINECS	Contact for details

Quality Control

Our 2-Bromo-4-(Difluoromethoxy)Pyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and industry standards for research and commercial use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.