Description

4-(Trifluoromethoxy)Pyridin-2-Amine is a high-value fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique trifluoromethoxy-substituted pyridine core offers significant advantages in modulating the physicochemical properties of target molecules, enhancing metabolic stability and lipophilicity. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries seeking to develop novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors, antiviral agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethoxy group can improve biological activity and environmental profile.
• Material Science Precursor: Employed in the synthesis of functionalized ligands for catalysis and as a monomer or modifier for specialty polymers and advanced materials.
• Chemical Biology Probe Development: Serves as a versatile scaffold for creating molecular probes and tool compounds to study biological pathways and protein function.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	4-(Trifluoromethoxy)Pyridin-2-Amine
CAS No.	1206980-54-2
Molecular Formula	C6H5F3N2O
Molecular Weight	178.11 g/mol
Synonyms	2-Amino-4-(trifluoromethoxy)pyridine; 4-(Trifluoromethoxy)-2-pyridinamine; 2-Pyridinamine, 4-(trifluoromethoxy)-; 4-(Trifluoromethoxy)pyridin-2-ylamine; 4-Trifluoromethoxypyridin-2-amine; 2-Amino-4-trifluoromethoxypyridine
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethoxy)Pyridin-2-Amine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring full traceability and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. Keep away from incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.