Description

2-Chloro-5-(Difluoromethoxy)Pyridine is a high-value halogenated pyridine derivative serving as a critical building block in advanced organic synthesis. This compound matters for its unique molecular architecture, which combines a chlorine substituent with a difluoromethoxy group on the pyridine ring, enabling precise modulation of electronic and steric properties in target molecules. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, where the difluoromethoxy group can enhance metabolic stability and bioavailability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis for asymmetric synthesis.
• Material Science Research: Employed in the synthesis of functionalized polymers and liquid crystals, where its halogenated structure can influence material properties.
• Custom Synthesis and Contract Manufacturing: An essential starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	2-Chloro-5-(Difluoromethoxy)Pyridine
CAS No.	1206980-28-0
Molecular Formula	C6H4ClF2NO
Molecular Weight	179.55 g/mol
Synonyms	2-Chloro-5-(difluoromethoxy)pyridine; 5-(Difluoromethoxy)-2-chloropyridine; Pyridine, 2-chloro-5-(difluoromethoxy)-; 2-Chloro-5-difluoromethoxypyridine
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-(Difluoromethoxy)Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis stages.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.