Description

n-Benzylnaltrindole Hydrochloride is a highly selective and potent antagonist for the delta opioid receptor (DOR). This compound is a critical research tool for investigating the complex pharmacology of opioid receptors and their role in pain modulation, addiction, and neurological disorders. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and contract research organizations (CROs) focused on neuroscience and analgesic drug discovery.

Application

• Neuroscience Research: A key pharmacological tool for studying delta opioid receptor (DOR) signaling pathways and function in the central nervous system.
• Analgesic Drug Discovery: Used in preclinical studies to evaluate the role of DOR antagonism in pain management and to develop novel, non-addictive pain therapeutics.
• Behavioral Pharmacology: Employed in animal models to investigate the effects of DOR blockade on addiction, reward, depression, and anxiety-related behaviors.
• Biochemical Assays: Serves as a reference standard in receptor binding assays, functional cellular assays (e.g., cAMP inhibition), and autoradiography studies.
• Mechanistic Studies: Helps elucidate the differential roles of opioid receptor subtypes (mu, delta, kappa) in various physiological and pathological processes.

Basic Information

Product Name	n-Benzylnaltrindole Hydrochloride
CAS No.	1206487-81-1
Molecular Formula	C34H37N3O4 • HCl
Molecular Weight	580.14 g/mol
Synonyms	BNTI Hydrochloride; Benzylnaltrindole HCl; n-Benzylnaltrindole HCl; 17-Cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14-dihydroxy-6,7-2',3'-indolomorphinan-7a-spiro-1'-benzylpyrrolidine Hydrochloride; N-Benzylnaltrindole Hydrochloride; δ-Opioid Receptor Antagonist BNTI; N-Bn-NTI HCl
EINECS	Contact for details

Quality Control

Our n-Benzylnaltrindole Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, generated using validated analytical methods such as HPLC, NMR, and mass spectrometry. We support research compliance with traceable documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm
Solubility	Soluble in DMSO, Methanol; slightly soluble in Water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.