Description

4'-Dimethylamino 7,8-Dihydroxyflavone Hydrobromide is a specialized synthetic flavonoid derivative, a high-purity research chemical of significant interest in pharmacological and biochemical studies. This compound matters as a potent and selective tool compound, primarily recognized for its activity as a TrkB receptor agonist, facilitating research in neurotrophic signaling pathways. It is essential for researchers and developers in the pharmaceutical, biotechnology, and academic sectors focused on neuroscience, neuroprotection, and the development of novel therapeutic agents for neurological disorders.

Application

• Neuroscience Research: As a selective TrkB agonist for studying BDNF/TrkB signaling, neurogenesis, and synaptic plasticity.
• Drug Discovery & Development: A key pharmacological tool and reference standard in high-throughput screening and lead optimization for neurological diseases.
• Biochemical Assays: Used in in vitro and cell-based assays to investigate mechanisms of neuroprotection and neuronal survival.
• Academic & Institutional Research: Fundamental research in universities and institutes exploring the therapeutic potential of flavonoid derivatives.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development and validation in quality control laboratories.
• Preclinical Studies: Utilized in animal model research to evaluate efficacy in conditions like depression, Alzheimer's disease, and Parkinson's disease.

Basic Information

Product Name	4'-Dimethylamino 7,8-Dihydroxyflavone Hydrobromide
CAS No.	1205548-00-0
Molecular Formula	C₁₇H₁₆BrNO₄
Molecular Weight	378.22 g/mol
Synonyms	7,8-Dihydroxy-4'-dimethylaminoflavone Hydrobromide; 4'-Dimethylamino-7,8-dihydroxyflavone HBr; TrkB Agonist; 7,8-DHF HBr (dimethylamino analog); 4'-DMA-7,8-DHF HBr; 2-(4-(Dimethylamino)phenyl)-5,6-dihydroxy-4H-chromen-4-one hydrobromide; 5,6-Dihydroxy-2-[4-(dimethylamino)phenyl]-4H-1-benzopyran-4-one hydrobromide
EINECS	Contact for details

Quality Control

Our 4'-Dimethylamino 7,8-Dihydroxyflavone Hydrobromide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with the standards required for pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.