Description

Ido Inhibitor 1 is a potent and selective small molecule inhibitor of the indoleamine 2,3-dioxygenase 1 (IDO1) enzyme. This compound is critical for modulating tryptophan metabolism and the kynurenine pathway, which are key immune checkpoint mechanisms in the tumor microenvironment. It is primarily utilized by pharmaceutical R&D teams and academic researchers focused on developing novel immunotherapies for oncology applications.

Application

• Immuno-oncology Research: A key tool compound for investigating the role of the IDO1 pathway in tumor immune evasion and for evaluating combination therapies.
• Drug Discovery & Development: Serves as a reference standard and pharmacological probe in high-throughput screening and lead optimization campaigns targeting IDO1.
• Preclinical Studies: Used in in vitro and in vivo models to validate target engagement, assess pharmacokinetics, and demonstrate proof-of-concept for IDO1 inhibition.
• Biochemical Assay Development: Employed as a control inhibitor to establish and validate enzymatic assays for IDO1 activity screening.
• Mechanistic Biology: Facilitates studies on the interplay between metabolic reprogramming and immune cell function within the tumor microenvironment.
• Autoimmune & Inflammatory Disease Research: Investigated for potential applications in conditions where tryptophan metabolism and immune tolerance are dysregulated.

Basic Information

Product Name	Ido Inhibitor 1
CAS No.	1204669-37-3
Molecular Formula	C₂₁H₂₀F₃N₅O₃
Molecular Weight	447.41 g/mol
Synonyms	INCB024360; Epacadostat; (1R,2R,5S)-3-(6-Amino-9H-purin-9-yl)-5-((4-fluorophenyl)thio)cyclopentane-1,2-diol; 4-fluoro-α-methyl-1H-indole-3-ethanamine; IDO1 Inhibitor; Indoleamine 2,3-Dioxygenase 1 Inhibitor; INCB 024360
EINECS	Contact for details

Quality Control

Our Ido Inhibitor 1 is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR for structural confirmation, and MS for identity verification. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to support your regulatory and documentation requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion [M+H]+
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.