Description

2,6-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine is a high-value, organoboron building block essential for modern synthetic chemistry. Its core value lies in enabling efficient carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in pharmaceutical and advanced materials research. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and organic electronics industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for fluorine-containing drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used to introduce the difluoropyridine moiety into novel herbicides, fungicides, and insecticides, enhancing their biological activity and environmental stability.
• Material Science: Serves as a monomer or building block for creating advanced organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters and charge transport layers.
• Ligand & Catalyst Development: Employed in the research and development of novel ligands and organometallic catalysts for asymmetric synthesis and other catalytic processes.
• Chemical Biology & Diagnostics: Utilized as a tagging or labeling reagent in probe development for imaging and diagnostic applications due to the versatility of the boronic ester group.
• Academic & Contract Research: A fundamental reagent for methodological development and complex molecule construction in academic laboratories and CROs (Contract Research Organizations).

Basic Information

Product Name	2,6-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
CAS No.	1204333-58-3
Molecular Formula	C11H14BF2NO2
Molecular Weight	253.04 g/mol
Synonyms	2,6-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,6-difluoropyridine; 2,6-Difluoropyridine-4-boronic acid pinacol ester; 2,6-Difluoro-4-pyridinylboronic acid pinacol ester; 4-Borono-2,6-difluoropyridine pinacol ester; 2,6-Difluoro-4-(pinacolatoboron)pyridine; PINACOL 2,6-DIFLUORO-4-PYRIDINEBORONATE
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for high-purity synthetic intermediates. Every batch is characterized by NMR (1H, 13C, 19F, 11B) and HPLC to confirm structural identity and purity. Certificates of Analysis (COA) detailing lot-specific results are available upon request. We support cGMP (current Good Manufacturing Practice) production for pharmaceutical applications and can provide materials manufactured under appropriate quality management systems.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
1H NMR Purity	≥95.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.