Description

(Cyclopropyldifluoromethyl)Benzene is a high-value fluorinated aromatic building block characterized by its unique cyclopropyl and difluoromethyl substituents. This compound is critical for introducing lipophilicity and metabolic stability into advanced molecular architectures, making it a sought-after intermediate in modern synthetic chemistry. It is primarily needed by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, as well as by specialty chemical manufacturers producing advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and inflammatory diseases.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides, fungicides, and insecticides where the difluoromethyl group enhances bioactivity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated organic semiconductors and liquid crystal compounds for display technologies.
• Advanced Polymer Modification: Employed to incorporate fluorine into polymer backbones to improve chemical resistance, thermal stability, and surface properties.
• Cross-Coupling Reactions: A valuable substrate in Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Fluorine Chemistry Research: An important reagent in academic and industrial laboratories studying the effects of fluorine substitution on physical and chemical properties.

Basic Information

Product Name	(Cyclopropyldifluoromethyl)Benzene
CAS No.	1204296-06-9
Molecular Formula	C10H10F2
Molecular Weight	168.18 g/mol
Synonyms	Benzene, (cyclopropyldifluoromethyl)-; α-Cyclopropyl-α,α-difluorotoluene; (Cyclopropyl-difluoromethyl)-benzene; 1-(Cyclopropyl)-2,2-difluoro-1-phenylethane; Difluorocyclopropylmethylbenzene; (Cyclopropyl)(difluoro)methylbenzene; α-Cyclopropyl-α,α-difluoromethylbenzene
EINECS	Contact for details

Quality Control

Our (Cyclopropyldifluoromethyl)Benzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical properties is provided with each shipment to guarantee consistency and support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.