Description

(Cyclobutyldifluoromethyl)Benzene is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. Its core value lies in the unique reactivity and physicochemical properties imparted by the cyclobutyl and difluoromethyl groups, enabling precise molecular modifications. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, where it serves as a key intermediate for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and CNS-active molecules.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides and fungicides, where the difluoromethyl group can enhance bioavailability and metabolic stability.
• Material Science Precursor: Serves as a building block for specialty polymers and liquid crystals, contributing unique electronic and steric properties.
• Organic Synthesis Reagent: Employed in cross-coupling reactions and as a source of the cyclobutyl-difluoromethyl moiety in complex molecule construction.
• Fluorine Chemistry Research: A valuable compound for academic and industrial research exploring new C-F bond formation strategies and the effects of fluorination.

Basic Information

Product Name	(Cyclobutyldifluoromethyl)Benzene
CAS No.	1204295-80-6
Molecular Formula	C11H12F2
Molecular Weight	182.21 g/mol
Synonyms	Benzene, (cyclobutyldifluoromethyl)-; α-Cyclobutyl-α,α-difluorotoluene; (Cyclobutyl-difluoromethyl)benzene; 1-(Cyclobutyldifluoromethyl)benzene; Difluoromethylcyclobutylbenzene; Cyclobutyl(difluoromethyl)benzene; 1204295-80-6
EINECS	Contact for details

Quality Control

Our (Cyclobutyldifluoromethyl)Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity and consistency, meeting the exacting standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and sources of ignition. Due to its fluoride/strong alkali chemical property, ensure it is stored separately from incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.