Description

1-Chloro-2-(1,1-Difluoroethyl)Benzene is a specialized fluorinated aromatic building block of significant interest in advanced organic synthesis. Its core value lies in the unique reactivity imparted by the difluoroethyl group adjacent to the chlorine substituent on the benzene ring, enabling precise molecular modifications. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries who require high-purity intermediates for constructing complex, bioactive molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated aromatic motifs to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the introduction of fluorine atoms can enhance efficacy and environmental profile.
• Material Science Precursor: Serves as a building block for synthesizing specialty polymers, liquid crystals, and organic electronic materials that benefit from fluorinated aromatic units.
• Cross-Coupling Reactions: The chlorine atom makes it a suitable substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to form new carbon-carbon and carbon-heteroatom bonds.
• Fluorine Chemistry Research: An important reagent for studying the effects of gem-difluoro groups on aromatic systems and for developing new fluorination methodologies.

Basic Information

Product Name	1-Chloro-2-(1,1-Difluoroethyl)Benzene
CAS No.	1204295-71-5
Molecular Formula	C8H7ClF2
Molecular Weight	176.59 g/mol
Synonyms	2-Chloro-α,α-difluoroethylbenzene; 1-Chloro-2-(1,1-difluoroethyl)benzene; Benzene, 1-chloro-2-(1,1-difluoroethyl)-; o-Chloro-α,α-difluoroethylbenzene; 2-(1,1-Difluoroethyl)chlorobenzene; (2-Chlorophenyl)(difluoro)methane
EINECS	Contact for details

Quality Control

Our 1-Chloro-2-(1,1-Difluoroethyl)Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment ensures material consistency and reliability for your critical research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.