Description

1-Chloro-3-(1,1-Difluoroethyl)Benzene is a high-purity, halogenated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where its unique difluoroethyl and chloro substituents enable precise modulation of biological activity and physicochemical properties. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) and metabolic diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the difluoroethyl group can enhance lipophilicity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorine-containing components in electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer & Resin Modifier: Incorporated to introduce fluorine into polymer chains, improving chemical resistance, thermal stability, and surface properties of high-performance materials.
• Cross-Coupling Reactions: Utilized in palladium-catalyzed reactions (e.g., Suzuki, Negishi) as an electrophilic coupling partner for constructing biaryl systems.
• Fluorine Chemistry Research: A valuable reagent for academic and industrial research exploring new fluorination methodologies and the effects of fluorine atoms in molecular design.

Basic Information

Product Name	1-Chloro-3-(1,1-Difluoroethyl)Benzene
CAS No.	1204295-57-7
Molecular Formula	C8H7ClF2
Molecular Weight	176.59 g/mol
Synonyms	3-Chloro-α,α-difluoroethylbenzene; 1-Chloro-3-(1,1-difluoroethyl)benzene; m-Chloro-α,α-difluoroethylbenzene; (3-Chlorophenyl)difluoroethane; 1-(3-Chlorophenyl)-1,1-difluoroethane; Benzene, 1-chloro-3-(1,1-difluoroethyl)-; 3-(1,1-Difluoroethyl)chlorobenzene
EINECS	Contact for details

Quality Control

Our 1-Chloro-3-(1,1-Difluoroethyl)Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatography (GC/HPLC) and spectroscopy (NMR, IR), to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed batch-specific results are provided to guarantee compliance with your research and process development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from strong acids and organic solvents. Recommended storage temperature is 2-8°C for long-term stability. Keep container tightly sealed when not in use to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Purity (HPLC)	≥ 96.5%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.