Description

Methyl 3-(Trifluoromethyl)Isonicotinate is a high-value fluorinated pyridine derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its core value lies in the trifluoromethyl group, which imparts unique metabolic stability and lipophilicity to target molecules, making it indispensable for modern pharmaceutical and agrochemical research. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex, bioactive molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the CF3 group enhances biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of fluorinated liquid crystals, organic semiconductors, and polymers with tailored electronic properties.
• Chemical Biology Probes: Utilized to create fluorinated analogs of natural products or biomarkers for metabolic and imaging studies.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	Methyl 3-(Trifluoromethyl)Isonicotinate
CAS No.	1203952-88-8
Molecular Formula	C8H6F3NO2
Molecular Weight	205.13 g/mol
Synonyms	Methyl 3-(trifluoromethyl)pyridine-4-carboxylate; 4-Pyridinecarboxylic acid, 3-(trifluoromethyl)-, methyl ester; 3-Trifluoromethyl-isonicotinic acid methyl ester; Methyl 3-trifluoromethylisonicotinate; Isonicotinic acid, 3-(trifluoromethyl)-, methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 3-(Trifluoromethyl)Isonicotinate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, impurity profiles, and physical data. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong bases and strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.