Description

Mln 8054 o-β-D-Glucuronide is a high-purity biochemical reference standard and synthetic intermediate, specifically the glucuronide conjugate of a key metabolite. This compound is critical for analytical method development, pharmacokinetic studies, and metabolic pathway research, providing a reliable standard for accurate quantification and identification. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers of diagnostic kits for use in drug metabolism and disposition (DMPK) studies, bioanalytical validation, and impurity profiling.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantification of drug metabolites in biological matrices via LC-MS/MS or HPLC.
• Drug Metabolism & Pharmacokinetics (DMPK): Essential for in vitro and in vivo studies to understand glucuronidation pathways, metabolic stability, and bioavailability.
• Bioanalytical Method Development: Serves as a critical standard for developing and validating robust analytical methods in compliance with FDA/ICH guidelines.
• Impurity Characterization: Employed to identify and quantify glucuronide-related impurities in active pharmaceutical ingredient (API) batches.
• Diagnostic Reagent Synthesis: Acts as a key intermediate or component in the synthesis of reagents for clinical diagnostic assays.
• Enzymology Research: Used as a substrate to study the activity of UDP-glucuronosyltransferase (UGT) enzymes.

Basic Information

Product Name	Mln 8054 o-β-D-Glucuronide
CAS No.	1203589-02-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	o-β-D-Glucuronide, Mln-8054 glucuronide, Drug metabolite Mln 8054 glucuronide, Mln8054-O-β-D-glucuronide, β-D-Glucopyranuronic acid conjugate, UDP-glucuronosyltransferase metabolite, Phase II metabolite conjugate, Acyl glucuronide derivative
EINECS	Contact for details

Quality Control

Every batch of Mln 8054 o-β-D-Glucuronide is manufactured under a strict quality management system and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our products are suitable for research and development use under current Good Manufacturing Practice (cGMP) principles. Comprehensive Certificates of Analysis (COA) detailing purity, assay, and impurity profiles by HPLC/LC-MS are provided with each shipment to support your regulatory and quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive) and must be handled under anhydrous conditions to maintain stability. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.