Description

Cyclotraxin B CAS NO 1203586-72-4 is a potent and selective small molecule inhibitor of the Trk family of neurotrophin receptors, specifically designed for research applications. This compound is crucial for studying the role of neurotrophin signaling in neuronal survival, differentiation, and pain pathways. It is an essential tool for researchers in the fields of neuroscience, oncology, and pharmacology, enabling the development of novel therapeutic strategies for neurological disorders and cancers.

Application

• Neuroscience Research: A key reagent for investigating neurotrophin signaling, neuronal development, and synaptic plasticity in vitro and in vivo models.
• Oncology Studies: Used to study the role of Trk receptors in tumorigenesis, particularly in cancers where NTRK gene fusions are drivers, such as certain sarcomas and carcinomas.
• Pain Research: Employed to explore the mechanisms of chronic pain and to validate Trk receptors as targets for next-generation analgesic drugs.
• Drug Discovery & Development: Serves as a pharmacological tool and reference standard in high-throughput screening and lead optimization programs targeting Trk kinases.
• Cell Biology: Utilized to dissect specific downstream signaling pathways (e.g., MAPK, PI3K/Akt) activated by neurotrophin binding to Trk receptors.
• Academic & Pharmaceutical R&D: A critical component for basic research and preclinical studies in university laboratories and biopharmaceutical companies.

Basic Information

Product Name	Cyclotraxin B
CAS No.	1203586-72-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Cyclotraxin B; CTXB; Trk inhibitor Cyclotraxin B; Neurotrophin receptor inhibitor; Tropomyosin receptor kinase inhibitor; NTRK inhibitor; (3aS,4R,9bR)-8-(2,6-Dichlorobenzyl)-4-(pyridin-2-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-3,6(7H)-dione
EINECS	Contact for details

Quality Control

Our Cyclotraxin B is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for critical research. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, potency, and other critical parameters to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic (moisture-sensitive) nature, the container should be allowed to reach room temperature before opening to prevent condensation and moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.