Description

Pu-H71 Hydrate is a potent and selective inhibitor of the 90 kDa heat shock protein (Hsp90), a molecular chaperone critical for the stability and function of numerous oncogenic client proteins. This targeted mechanism makes it a valuable research-grade chemical for investigating cancer biology and therapeutic pathways. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in oncology drug discovery and preclinical development.

Application

• Oncology Research: A key tool compound for studying Hsp90 inhibition and its effects on tumor cell proliferation, survival, and apoptosis.
• Mechanistic Studies: Used to validate Hsp90 as a therapeutic target and to understand its role in protein folding and degradation pathways.
• Preclinical Drug Development: Serves as a reference standard or lead compound in the development of novel Hsp90-targeted anti-cancer agents.
• Biochemical Assays: Employed in high-throughput screening (HTS) and in vitro assays to evaluate Hsp90 inhibitor potency and selectivity.
• Signal Transduction Research: Useful for probing the downstream effects of Hsp90 inhibition on various oncogenic signaling cascades (e.g., HER2, AKT, RAF).

Basic Information

Product Name	Pu-H71 Hydrate
CAS No.	1202865-65-3
Molecular Formula	C₁₇H₂₁ClN₆O₂ • xH₂O
Molecular Weight	376.84 g/mol (anhydrous basis)
Synonyms	PU-H71 Hydrate; PUH71 Hydrate; 8-[(6-Iodo-1,3-benzodioxol-5-yl)thio]-9-(3-(isopropylamino)propyl)-9H-purin-6-amine hydrate; Hsp90 Inhibitor PU-H71 Hydrate; SNX-5422 mesylate impurity; (Research Code) PU-H71
EINECS	Contact for details

Quality Control

Our Pu-H71 Hydrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and KF titration for water content. A detailed Certificate of Analysis (COA) is provided, ensuring the material meets the stringent specifications required for research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤5.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.