Description

1-13C-D-Phenylalanine is a stable isotope-labeled amino acid, specifically a deuterated and carbon-13 enriched form of the D-isomer of phenylalanine. This compound is a critical tool for advanced research and development, enabling precise metabolic and pharmacokinetic studies through mass spectrometry and NMR spectroscopy. It is primarily required by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in drug discovery, proteomics, and metabolic pathway analysis.

Application

• Internal Standard for LC-MS/MS: Used as a quantitative reference standard in bioanalytical method development for drug and biomarker analysis.
• Metabolic Flux Analysis (MFA): Employed in 13C tracing experiments to study central carbon metabolism in cell cultures and model organisms.
• Proteomics Research: Serves as a stable isotope-labeled building block in SILAC (Stable Isotope Labeling by Amino acids in Cell culture) for quantitative proteomics.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Facilitates the accurate tracking and quantification of drug metabolites in preclinical and clinical studies.
• Neurochemical Research: Used in studies investigating phenylalanine metabolism and its role in neurological disorders.
• Diagnostic Agent Development: A potential component in the development of advanced diagnostic probes for metabolic diseases like phenylketonuria (PKU).

Basic Information

Product Name	1-13C-D-Phenylalanine
CAS No.	1202063-94-2
Molecular Formula	C9H11D13CNO2
Molecular Weight	~168.19 g/mol
Synonyms	(2R)-2-Amino-3-phenyl(1-13C)propanoic-3,3-d2 acid; D-Phenylalanine-1-13C,d2; (R)-2-Amino-3-phenyl(1-13C)propionic-3,3-d2 acid; 1-13C-D-Phe; [1-13C]-(R)-Phenylalanine-3,3-d2; Deuterated 1-13C-D-Phenylalanine; Stable Isotope Labeled D-Phenylalanine
EINECS	Contact for details

Quality Control

Our 1-13C-D-Phenylalanine is manufactured under strict quality systems to ensure the highest isotopic and chemical purity for research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (by NMR or MS), chemical purity (by HPLC), chiral purity, and other critical parameters. We adhere to relevant industry standards for stable isotope-labeled compounds to guarantee reproducible and reliable performance in your sensitive analytical workflows.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (13C)	≥ 99 atom % 13C
Isotopic Enrichment (D)	≥ 98 atom % D
Chiral Purity (HPLC)	≥ 99.0% (D-isomer)
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.