Description

Vinflunine Tartrate is a high-purity, synthetic vinca alkaloid derivative, specifically formulated as the tartrate salt. This compound is a critical active pharmaceutical ingredient (API) valued for its potent antitumor properties, primarily targeting microtubule dynamics. It is essential for pharmaceutical R&D and manufacturing, particularly for researchers and producers developing advanced chemotherapeutic agents for the treatment of metastatic bladder cancer and other solid tumors.

Application

• Pharmaceutical Active Ingredient (API): Primary use as the active component in injectable chemotherapeutic formulations.
• Oncology Research: A key reference standard and investigational compound in preclinical and clinical studies for novel cancer therapies.
• Anticancer Drug Development: Serves as a building block for synthesizing new derivatives and conjugates in medicinal chemistry.
• Biochemical Research: Used in studies of tubulin binding, cell cycle arrest, and apoptosis mechanisms.
• GMP Manufacturing: Sourced by contract manufacturing organizations (CMOs) for the commercial production of finished dosage forms under Good Manufacturing Practices.
• Quality Control & Analytical Testing: Employed as a certified reference material (CRM) in HPLC and LC-MS methods for assay and impurity profiling.

Basic Information

Product Name	Vinflunine Tartrate
CAS No.	1201898-17-0
Molecular Formula	C49H58N4O8 • C4H6O6
Molecular Weight	943.1 g/mol (for the salt)
Synonyms	Vinflunine Ditartrate; BMS-710485; 20',20'-Difluoro-3',4'-dihydrovinorelbine Tartrate; 20',20'-Difluoro-3',4'-dihydro-5'-norvinorelbine Tartrate; (3'aR,4R,5S,5'aR,10'bR,13aR)-4-(Acetyloxy)-3'a-ethyl-9-((5S,7R,9S)-5-ethyl-5-hydroxy-9-(methoxycarbonyl)-1,4,5,6,7,8,9,10-octahydro-2H-3,7-methanoazacycloundecino[5,4-b]indol-9-yl)-5-hydroxy-8-methoxy-6-methyl-3'a,4,5,5'a,6,11,12,13a-octahydro-1H-indolizino[8,1-cd]carbazole-5-carboxylic acid methyl ester (2R,3R)-2,3-dihydroxybutanedioate (1:2)
EINECS	Contact for details

Quality Control

Our Vinflunine Tartrate is manufactured under strict quality systems to ensure it meets the stringent requirements for pharmaceutical intermediates and APIs. Each batch undergoes comprehensive analytical testing, including HPLC for purity and assay, identification by spectroscopic methods, and rigorous control of impurities and residual solvents. A Certificate of Analysis (COA) documenting full compliance with agreed specifications is provided with every shipment. We support development and commercial projects requiring ICH stability data and regulatory filing support.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator after opening to prevent degradation. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Water Content (KF)	≤2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Related Substances (HPLC)	Total impurities ≤2.0%; Any single unknown impurity ≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.