Description

Bd140 [For Albumin Binding Assay] is a specialized chemical probe designed for the quantitative assessment of small molecule binding to human serum albumin (HSA). This compound matters for researchers and developers in drug discovery and pharmacokinetics, as albumin binding is a critical parameter influencing a drug's distribution, metabolism, and efficacy. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on early-stage ADME (Absorption, Distribution, Metabolism, and Excretion) profiling and lead optimization.

Application

• Primary Application: Quantitative determination of human serum albumin (HSA) binding affinity for drug candidates and new chemical entities.
• Drug Discovery Screening: High-throughput screening (HTS) assays to rank compound libraries based on their plasma protein binding characteristics.
• ADME/Tox Studies: A key tool in preclinical pharmacokinetic studies to predict volume of distribution and half-life of investigational drugs.
• Mechanistic Studies: Investigating binding site specificity (Site I vs. Site II) on the albumin molecule.
• Method Development: Used as a reference or competitor compound in developing new fluorescence-based, UV, or LC-MS/MS binding assay protocols.
• Biomolecular Interaction Analysis: Supporting surface plasmon resonance (SPR) or isothermal titration calorimetry (ITC) studies for binding kinetics.

Basic Information

Product Name	Bd140 [For Albumin Binding Assay]
CAS No.	1201643-08-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Bd-140; BD 140; Albumin Binding Probe Bd140; HSA Binding Assay Probe; Fluorescent Albumin Binder; Serum Albumin Ligand; Pharmacokinetic Screening Agent; Drug-Protein Interaction Probe
EINECS	Contact for details

Quality Control

Every batch of Bd140 is manufactured and tested under strict quality management systems to ensure consistency and reliability for sensitive research applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, providing detailed data on purity, identity, and performance in standardized binding assays.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert atmosphere for long-term stability. For short-term use, the material may be stored desiccated at 2-8°C. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	Solid (color to be specified on COA)
Identification (HPLC/MS)	Conforms to reference
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 1.0%
Performance (Binding Assay)	Provides consistent signal-to-noise ratio in standardized HSA binding assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.