Description

Ipi 145 is a high-purity, non-nucleoside reverse transcriptase inhibitor (NNRTI) compound, identified by CAS No. 1201438-56-3. It is a critical intermediate in the research and development of novel antiviral pharmaceuticals, particularly for the treatment of HIV. This compound is essential for pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of next-generation therapeutic agents.

Application

• Pharmaceutical Intermediate: Primary use as a key building block in the synthesis of advanced non-nucleoside reverse transcriptase inhibitors (NNRTIs) for antiviral therapies.
• Biochemical Research: Used as a reference standard and active compound in virology and pharmacology research to study HIV replication mechanisms.
• Drug Discovery & Development: Serves as a core scaffold for medicinal chemistry programs aimed at developing new antiviral candidates with improved efficacy and resistance profiles.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the cGMP production of active pharmaceutical ingredients (APIs) in clinical trial materials.
• Academic Research: Utilized in university and institutional labs for fundamental studies on enzyme inhibition and structure-activity relationships (SAR).

Basic Information

Product Name	Ipi 145
CAS No.	1201438-56-3
Molecular Formula	C₂₀H₂₀N₆O₂
Molecular Weight	376.41 g/mol
Synonyms	IPI-145; Duvelisib intermediate; INK1197; 2-[(1S)-1-(9H-Purin-6-ylamino)ethyl]-5-fluoro-3-phenylquinazolin-4(3H)-one; (S)-2-(1-(9H-Purin-6-ylamino)ethyl)-5-fluoro-3-phenylquinazolin-4(3H)-one; 5-Fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)ethyl]-4(3H)-quinazolinone
EINECS	Contact for details

Quality Control

Our Ipi 145 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via NMR and mass spectrometry. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research and development grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.