Description

(5E)-7-Oxozeaenol is a potent and selective small-molecule inhibitor of TAK1 (TGF-β-activated kinase 1) and VEGF receptor 2 (VEGFR2) signaling pathways. This compound matters for researchers and developers in the life sciences sector as it serves as a critical pharmacological tool for studying inflammation, cancer biology, and angiogenesis. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on developing novel therapeutics for cancer, autoimmune, and inflammatory diseases.

Application

• Biochemical Research: Used as a selective inhibitor to study the role of TAK1 and VEGFR2 in cellular signaling cascades, inflammation, and apoptosis.
• Oncology Research: Investigated for its potential to inhibit tumor growth and angiogenesis in various cancer cell lines and preclinical models.
• Inflammation & Immunology Studies: Employed to elucidate pathways in autoimmune diseases, rheumatoid arthritis, and other inflammatory conditions.
• Drug Discovery & Development: Serves as a lead compound or reference standard in high-throughput screening and structure-activity relationship (SAR) studies.
• Cell Biology: Utilized to probe MAPK and NF-κB signaling pathways in cell culture experiments.
• Pharmacology: Acts as a tool compound for validating drug targets and understanding mechanism of action in disease models.

Basic Information

Product Name	(5E)-7-Oxozeaenol
CAS No.	1198574-97-8
Molecular Formula	C22H28O6
Molecular Weight	388.46 g/mol
Synonyms	5Z-7-Oxozeaenol; LL-Z1640-2; TAK1 Inhibitor (5Z)-7-Oxozeaenol; 7-Oxozeaenol; (5Z)-7-Oxo-zeaenol; Angiogenesis Inhibitor LL-Z1640-2; VEGFR2/TAK1 Inhibitor
EINECS	Contact for details

Quality Control

Our (5E)-7-Oxozeaenol is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity confirmation and identity verification by spectroscopic methods (NMR, MS), to ensure it meets the high standards required for research use. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. Due to its hygroscopic (moisture-sensitive) nature, the container should be sealed under dry conditions and allowed to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.