Description

4-Ethynyl-3-Fluoropyridine is a high-value, multi-functional heterocyclic building block featuring both a fluorine substituent and an ethynyl group. This unique molecular architecture makes it a critical intermediate for the synthesis of complex molecules in advanced research and development. It is primarily sought after by pharmaceutical, agrochemical, and materials science industries for constructing novel active compounds and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, leveraging the fluorine atom for enhanced biological activity and metabolic stability.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organometallic chemistry.
• Material Science Building Block: Employed in the synthesis of advanced polymers, liquid crystals, and organic electronic materials due to its rigid, conjugated ethynyl group.
• Chemical Biology Probe: Utilized in click chemistry (e.g., CuAAC reactions) for bioconjugation and labeling applications in diagnostic and proteomic research.

Basic Information

Product Name	4-Ethynyl-3-Fluoropyridine
CAS No.	1196156-81-6
Molecular Formula	C7H4FN
Molecular Weight	121.11 g/mol
Synonyms	3-Fluoro-4-ethynylpyridine; 4-Ethynyl-3-fluoropyridine; 3-Fluoro-4-pyridylethyne; 4-(Ethynyl)-3-fluoropyridine; 3-Fluoropyridin-4-ylacetylene
EINECS	Contact for details

Quality Control

Our 4-Ethynyl-3-Fluoropyridine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and consistent performance. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. This compound is light-sensitive and easily oxidized; prolonged exposure to air or light should be avoided.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.