Description

5-Ethynyl-2-(Trifluoromethyl)Pyridine is a high-value, multi-functional heterocyclic building block characterized by its reactive ethynyl group and electron-withdrawing trifluoromethyl substituent. This compound matters for its critical role in facilitating rapid and efficient molecular assembly, particularly in the synthesis of complex pharmaceutical intermediates and advanced materials. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of novel pesticides and herbicides, leveraging the biological activity imparted by the pyridine and trifluoromethyl motifs.
• Material Science Precursor: Serves as a building block for organic electronic materials, metal-organic frameworks (MOFs), and polymers due to its conjugated alkyne functionality.
• Click Chemistry Reagent: The terminal alkyne group makes it an ideal participant in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions for bioconjugation and polymer functionalization.
• Ligand Synthesis: Employed in the preparation of specialized ligands for catalysis and coordination chemistry.
• Fluorinated Compound Research: Essential for studying the effects of fluorine introduction on the physicochemical properties of molecules in medicinal chemistry.

Basic Information

Product Name	5-Ethynyl-2-(Trifluoromethyl)Pyridine
CAS No.	1196155-24-4
Molecular Formula	C8H4F3N
Molecular Weight	171.12 g/mol
Synonyms	2-(Trifluoromethyl)-5-ethynylpyridine; 5-Ethynyl-2-(trifluoromethyl)pyridine; 5-Ethynyl-α,α,α-trifluoro-2-picoline; 2-Pyridinecarbonitrile, 5-ethynyl-α,α,α-trifluoro-; 5-Ethynyl-2-trifluoromethylpyridine; 5-Ethynyl-2-(trifluoromethyl)pyridine, 97%; 5-Ethynyl-α,α,α-trifluoro-2-picoline
EINECS	Contact for details

Quality Control

Our 5-Ethynyl-2-(Trifluoromethyl)Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and process chemistry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). The compound may be sensitive to moisture and air over prolonged periods; consider storage under an inert atmosphere for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.