Description

3-Pyridinemethanesulfonyl Chloride, 6-(Trifluoromethyl)- is a specialized heterocyclic building block featuring a reactive sulfonyl chloride group and a trifluoromethyl substituent. This compound matters as a critical intermediate for introducing the sulfonamide pharmacophore into target molecules, a key structural motif in modern medicinal chemistry. Pharmaceutical researchers and agrochemical developers need it for the synthesis of novel active ingredients, particularly in the creation of protease inhibitors, kinase inhibitors, and other biologically active compounds.

Application

• Pharmaceutical Intermediate: A key synthon for the development of sulfonamide-based drug candidates targeting various diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides with enhanced activity.
• Protease Inhibitor Development: Crucial for constructing molecules that inhibit specific proteases involved in viral, inflammatory, or oncogenic pathways.
• Kinase Inhibitor Scaffolds: Serves as a building block for creating potent and selective kinase inhibitors for cancer and other therapeutic areas.
• Chemical Biology Probes: Employed in the synthesis of activity-based probes (ABPs) for studying enzyme function and target engagement.
• Material Science Research: Potential monomer or modifier for creating functional polymers with specific surface properties.

Basic Information

Product Name	3-Pyridinemethanesulfonyl Chloride, 6-(Trifluoromethyl)-
CAS No.	1196152-24-5
Molecular Formula	C7H5ClF3NO2S
Molecular Weight	259.63 g/mol
Synonyms	6-(Trifluoromethyl)pyridine-3-methanesulfonyl chloride; 3-(Chlorosulfonylmethyl)-6-(trifluoromethyl)pyridine; 6-(Trifluoromethyl)-3-pyridylmethanesulfonyl chloride; (6-(Trifluoromethyl)pyridin-3-yl)methanesulfonyl chloride; 3-Pyridinemethanesulfonyl chloride, 6-(trifluoromethyl)-; 6-Trifluoromethyl-pyridine-3-methanesulfonyl chloride
EINECS	Contact for details

Quality Control

Our 3-Pyridinemethanesulfonyl Chloride, 6-(Trifluoromethyl)- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided for each lot to support your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.