Description

tert-Butyl 4-[(Chlorosulfonyl)Methyl]Piperidine-1-Carboxylate is a high-value, protected piperidine derivative featuring a reactive chlorosulfonyl group. This compound serves as a critical advanced pharmaceutical intermediate (API intermediate) for the synthesis of complex bioactive molecules. It is primarily utilized by research organizations and pharmaceutical manufacturers engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and inflammation.
• Sulfonamide Library Synthesis: The reactive chlorosulfonyl moiety enables efficient parallel synthesis of diverse sulfonamide-based compound libraries for high-throughput screening.
• Protease Inhibitor Development: Used in constructing pharmacophores for inhibitors of various protease enzymes, a significant target class in drug discovery.
• Chemical Biology Probes: Serves as a precursor for creating activity-based probes to study enzyme function and mechanism in biological systems.
• Agrochemical Research: Intermediate in the development of new active ingredients for crop protection products.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or research-grade conditions.

Basic Information

Product Name	tert-Butyl 4-[(Chlorosulfonyl)Methyl]Piperidine-1-Carboxylate
CAS No.	1196151-52-6
Molecular Formula	C12H22ClNO4S
Molecular Weight	311.83 g/mol
Synonyms	1-Boc-4-(chlorosulfonylmethyl)piperidine; 1-(tert-Butoxycarbonyl)-4-(chlorosulfonylmethyl)piperidine; 4-[(Chlorosulfonyl)methyl]-1-piperidinecarboxylic acid tert-butyl ester; tert-Butyl 4-(chlorosulfonylmethyl)piperidine-1-carboxylate; 1-Boc-4-(chloromethylsulfonyl)piperidine; 4-(Chlorosulfonylmethyl)piperidine-1-carboxylic acid tert-butyl ester; N-Boc-4-(chlorosulfonylmethyl)piperidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-[(Chlorosulfonyl)Methyl]Piperidine-1-Carboxylate is produced under strict quality management protocols. Every batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing key parameters such as assay and impurity profiles. Our quality systems support both research-grade and cGMP-grade supply requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥97.0% (Area Percent)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Individual unknown impurity ≤0.5%; Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.