Description

5-Bromo-2-Nitrobenzenesulphonylchloride is a high-purity, specialized aromatic sulfonyl chloride derivative used as a critical building block in advanced organic synthesis. Its reactive sulphonyl chloride group and strategically placed bromo and nitro substituents make it an invaluable reagent for constructing complex molecular architectures, particularly in pharmaceutical and agrochemical research. This compound is essential for medicinal chemists and process development scientists working on sulfonamide-based active pharmaceutical ingredients (APIs), specialty dyes, and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel sulfonamide drugs, including protease inhibitors, kinase inhibitors, and antibacterial agents.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and pesticides with sulfonamide backbones for enhanced efficacy.
• Dye and Pigment Manufacturing: Serves as a building block for creating specialized azo dyes and pigments with specific light-fastness and color properties.
• Polymer Chemistry: Employed in the synthesis of functional polymers and materials, such as sulfonated polymers for ion-exchange membranes.
• Chemical Biology & Proteomics: Acts as a reactive handle for bioconjugation and the development of activity-based probes targeting specific enzyme families.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.

Basic Information

Product Name	5-Bromo-2-Nitrobenzenesulphonylchloride
CAS No.	1193388-84-9
Molecular Formula	C6H3BrClNO4S
Molecular Weight	300.51 g/mol
Synonyms	5-Bromo-2-nitrobenzenesulfonyl chloride; 2-Nitro-5-bromobenzenesulfonyl chloride; Benzenesulfonyl chloride, 5-bromo-2-nitro-; 5-Bromo-2-nitrobenzene-1-sulfonyl chloride; 5-Bromo-2-nitrobenzenesulfonoyl chloride; 5-Bromo-2-nitro-phenylsulfonyl chloride
EINECS	Contact for details

Quality Control

Every batch of 5-Bromo-2-Nitrobenzenesulphonylchloride is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure consistency and purity. Our products meet the stringent requirements for advanced synthetic intermediates, with specifications tailored for research and development as well as scale-up processes. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profiles via validated methods such as HPLC, NMR, and IR spectroscopy.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.