Description

2-Methyl-3-(trifluoromethyl)benzenesulfonyl chloride is a specialized organosulfur reagent featuring a reactive sulfonyl chloride group and a trifluoromethyl substituent. This compound is highly valued for its role as a key synthetic intermediate in the development of advanced pharmaceutical and agrochemical molecules. It is primarily needed by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and crop protection industries for constructing sulfonamide linkages and introducing the metabolically stable trifluoromethyl group.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly those targeting enzymes via sulfonamide-based inhibitors.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the sulfonamide moiety and fluorine atoms enhance biological activity and environmental stability.
• Material Science Research: Employed in the development of specialty polymers and functional materials, such as sulfonated polymers for ion-exchange membranes.
• Chemical Biology Probes: Serves as a reagent for labeling proteins or modifying biomolecules to study biological pathways and interactions.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up production under cGMP or ISO standards for client-specific molecules.

Basic Information

Product Name	2-Methyl-3-(Trifluoromethyl)Benzenesulfonylchloride
CAS No.	1191545-46-6
Molecular Formula	C8H6ClF3O2S
Molecular Weight	258.64 g/mol
Synonyms	2-Methyl-3-(trifluoromethyl)benzenesulfonyl chloride; 3-Trifluoromethyl-o-toluenesulfonyl chloride; 2-Methyl-alpha,alpha,α-trifluoro-m-toluenesulfonyl chloride; 1-Methyl-2-(trifluoromethyl)benzene-6-sulfonyl chloride; 2-Methyl-3-trifluoromethylphenylsulfonyl chloride; m-Tolyl-3-trifluoromethyl sulfonyl chloride; Benzenesulfonyl chloride, 2-methyl-3-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 2-Methyl-3-(Trifluoromethyl)Benzenesulfonylchloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 96.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.