Description

3-Iodo-4-(Trifluoromethyl)-5-Azaindole is a high-value, multi-functional heterocyclic building block designed for advanced chemical synthesis. This compound is particularly significant for its unique molecular architecture, combining an iodine substituent and a trifluoromethyl group on an azaindole core, which is critical for modulating the physicochemical and biological properties of target molecules. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, including the development of kinase inhibitors and other bioactive small molecules.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly for targeted therapies.
• Medicinal Chemistry Research: Used extensively in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR).
• Agrochemical Development: Employed in the creation of new active ingredients for crop protection products.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Material Science: Potential building block for advanced organic electronic materials due to its halogenated and fluorinated structure.
• Custom Synthesis & Contract Manufacturing: A critical starting material for CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	3-Iodo-4-(Trifluoromethyl)-5-Azaindole
CAS No.	1190313-20-2
Molecular Formula	C8H4F3IN2
Molecular Weight	312.03 g/mol
Synonyms	3-Iodo-4-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine; 4-(Trifluoromethyl)-3-iodo-1H-pyrrolo[3,2-b]pyridine; 3-Iodo-4-trifluoromethyl-5-azaindole; 1H-Pyrrolo[3,2-b]pyridine, 3-iodo-4-(trifluoromethyl)-; 5-Azaindole, 3-iodo-4-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Every batch of 3-Iodo-4-(Trifluoromethyl)-5-Azaindole is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our standard quality commitment includes comprehensive analysis via HPLC, NMR, and MS to confirm a typical purity of ≥95% (by HPLC). A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all relevant specifications. We adhere to cGMP principles for pharmaceutical-grade materials upon request, ensuring supply chain integrity and batch-to-batch reliability for critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.