Description

Clomipramine D6 CAS NO 1190043-04-9 is a deuterium-labeled analog of the tricyclic antidepressant clomipramine, where six hydrogen atoms are replaced with the stable isotope deuterium. This compound is an essential internal standard for the precise and accurate quantification of clomipramine in complex biological matrices using advanced analytical techniques like LC-MS/MS. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and forensic toxicology labs engaged in drug metabolism and pharmacokinetics (DMPK) studies, bioanalytical method development, and therapeutic drug monitoring.

Application

• Internal Standard for Bioanalysis: Critical for quantitative LC-MS/MS analysis of clomipramine in plasma, serum, and urine to correct for matrix effects and instrument variability.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in preclinical and clinical studies to investigate the absorption, distribution, metabolism, and excretion (ADME) profile of clomipramine.
• Therapeutic Drug Monitoring (TDM): Enables accurate measurement of clomipramine levels in patient samples to optimize dosage and ensure therapeutic efficacy while minimizing side effects.
• Forensic and Clinical Toxicology: Supports the confirmation and quantification of clomipramine in cases of overdose or suspected poisoning.
• Pharmaceutical Impurity Profiling: Can be utilized as a reference standard to identify and quantify potential deuterated impurities in labeled drug substances.
• Stable Isotope Labeling Studies: Serves as a tracer in mechanistic studies to elucidate metabolic pathways.

Basic Information

Product Name	Clomipramine D6
CAS No.	1190043-04-9
Molecular Formula	C19H17D6ClN2
Molecular Weight	~327.88 g/mol
Synonyms	3-(3-Chloro-5,6-dihydro-5-[D3]methyl-6-[D3]methylidene-11H-dibenzo[b,e]azepin-11-yl)-N,N-[D6]dimethylpropan-1-amine; Clomipramine-d6; Deuterated Clomipramine; Clomipramine (hexadeuterated); 3-(3-Chloro-5,6-dihydro-5-(trideuteriomethyl)-6-(trideuteriomethylene)-11H-dibenzo[b,e]azepin-11-yl)-N,N-bis(trideuteriomethyl)propan-1-amine
EINECS	Contact for details

Quality Control

Every batch of Clomipramine D6 is manufactured and analyzed under strict quality control protocols to ensure the highest standards of isotopic purity and chemical identity. Our products undergo rigorous testing, including advanced spectroscopic and chromatographic methods, to guarantee compliance with research-grade specifications. A comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (e.g., D6 ≥ 99%), chemical purity, and analytical results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccation and storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99.0 atom % D (D6)
Chemical Purity	≥ 98.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.