Description

Amobarbital-D5 (Ethyl-D5) is a deuterated analog of the barbiturate derivative amobarbital, specifically labeled with five deuterium atoms on the ethyl side chain. This high-purity stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring analytical accuracy and reliability. It is primarily required by pharmaceutical research laboratories, forensic toxicology units, and contract research organizations (CROs) engaged in drug metabolism, pharmacokinetic studies, and regulatory bioanalysis.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of amobarbital in complex biological matrices such as plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in studies to track the absorption, distribution, metabolism, and excretion (ADME) of the parent drug.
• Forensic and Clinical Toxicology: Enables accurate identification and measurement of amobarbital in cases of overdose, poisoning, or compliance monitoring.
• Pharmaceutical R&D: Supports method development and validation in analytical laboratories during drug discovery and development phases.
• Reference Material: Serves as a certified reference material (CRM) for calibrating analytical instruments and ensuring data integrity.
• Regulatory Submissions: Facilitates the generation of compliant data for submissions to agencies like the FDA and EMA.

Basic Information

Product Name	Amobarbital-D5 (Ethyl-D5)
CAS No.	1190003-63-4
Molecular Formula	C11H13D5N2O3
Molecular Weight	~ 229.28 g/mol
Synonyms	5-Ethyl-5-(3-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidinetrione-ethyl-d5; Amobarbital-d5; 5-Ethyl-d5-5-isopentylbarbituric Acid; Amylobarbitone-d5; Amytal-d5; Ethyl-D5 Amobarbital; Deuterated Amobarbital Internal Standard
EINECS	Contact for details

Quality Control

Every batch of Amobarbital-D5 (Ethyl-D5) is manufactured and tested under strict quality management systems to ensure it meets the exacting standards required for analytical applications. We provide comprehensive Certificates of Analysis (COA) that detail isotopic purity, chemical purity, and confirm identity and strength. Our quality commitment aligns with the needs of GMP/GLP-compliant laboratories, ensuring reliability for critical research and regulatory work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Assay (HPLC)	≥98.0% (chemical purity)
Isotopic Purity	≥98.0 atom % D
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.