Description

7-Hydroxy Coumarin-13C3 is a stable isotope-labeled derivative of the naturally occurring compound umbelliferone, where three carbon atoms are replaced with the carbon-13 isotope. This product is essential for use as an internal standard in quantitative mass spectrometry, enabling highly accurate and precise analytical measurements. It is primarily required by research institutions, pharmaceutical companies, and contract research organizations (CROs) engaged in advanced pharmacokinetic studies, metabolic pathway analysis, and the development of bioanalytical methods.

Application

• Quantitative Mass Spectrometry: Serves as a critical internal standard for the accurate quantification of 7-hydroxycoumarin and its metabolites in complex biological matrices like plasma, urine, and tissue homogenates.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in tracer studies to investigate the absorption, distribution, metabolism, and excretion (ADME) profiles of coumarin-based compounds and drugs.
• Biomarker Analysis: Enables precise measurement of umbelliferone as a biomarker for specific enzymatic activities (e.g., cytochrome P450 isoforms) in clinical and preclinical research.
• Method Development and Validation: A key reagent for developing and validating robust, GLP-compliant LC-MS/MS methods in analytical laboratories.
• Stable Isotope Dilution Assays: Provides the foundation for highly specific assays that minimize matrix effects and improve data reliability in research.

Basic Information

Product Name	7-Hydroxy Coumarin-13C3
CAS No.	1189992-05-9
Molecular Formula	C9H6O3 (with three 13C atoms)
Molecular Weight	~165.1 g/mol (Contact for exact isotopic weight)
Synonyms	Umbelliferone-13C3; 7-Hydroxy-2H-1-benzopyran-2-one-13C3; 7-Hydroxy-2H-chromen-2-one-13C3; 7-HOC-13C3; 7-Hydroxycoumarin (13C3); 7-Hydroxy-2-oxo-2H-chromene-13C3; Skimmetin-13C3; Hydrangin-13C3
EINECS	Contact for details

Quality Control

Our 7-Hydroxy Coumarin-13C3 is manufactured under controlled conditions to ensure exceptional isotopic and chemical purity, critical for reliable analytical results. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment, chemical purity, and identity confirmation. We adhere to stringent quality management protocols to ensure batch-to-batch consistency and traceability for research and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Enrichment	≥99 atom % 13C (on three labeled positions)
Chemical Purity (HPLC)	≥95.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.