Description

Desmethyl Atomoxetine-D7 Hydrochloride Salt is a high-purity, deuterium-labeled internal standard critical for precise analytical quantification. This compound is essential for ensuring accuracy and reliability in sensitive mass spectrometry-based assays, particularly in pharmacokinetic and metabolism studies. It is primarily used by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities requiring validated reference materials for method development and quality control.

Application

• Internal Standard for LC-MS/MS Analysis: Used as a deuterated internal standard for the accurate quantification of atomoxetine and its metabolites in biological matrices like plasma and urine.
• Pharmaceutical Research & Development: Supports method development, validation, and bioanalytical studies for drug metabolism and pharmacokinetics (DMPK).
• Clinical Trial Support: Enables precise measurement of drug concentrations in patient samples during clinical trials for attention deficit hyperactivity disorder (ADHD) treatments.
• Forensic Toxicology: Assists in the confirmatory analysis and quantification of atomoxetine in forensic casework.
• Reference Standard for Impurity Profiling: Serves as a characterized reference material for identifying and quantifying related substances and degradants in active pharmaceutical ingredient (API) batches.
• Regulatory Compliance Testing: Facilitates testing that adheres to guidelines from regulatory bodies like the FDA and EMA, ensuring data integrity for submissions.

Basic Information

Product Name	Desmethyl Atomoxetine-D7 Hydrochloride Salt
CAS No.	1189961-95-2
Molecular Formula	C16H14D7NO•HCl
Molecular Weight	284.86 g/mol (approx.)
Synonyms	N-Methyl-3-phenyl-3-(o-tolyloxy)propylamine-D7 Hydrochloride; (R)-N-Methyl-3-phenyl-3-(2-methylphenoxy)propan-1-amine-D7 Hydrochloride; Tomoxetine-D7 Metabolite Hydrochloride; (3R)-N-Methyl-3-(2-methylphenoxy)-3-phenylpropylamine-D7 Hydrochloride; LY-139603-D7; Desmethyl Atomoxetine D7 HCl; d7-Desmethyl Atomoxetine HCl
EINECS	Contact for details

Quality Control

Every batch of Desmethyl Atomoxetine-D7 Hydrochloride Salt is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to support its use as a certified reference material. A detailed Certificate of Analysis (COA), including results from HPLC, NMR, and MS for identity, purity, and isotopic enrichment verification, is supplied with each shipment to ensure traceability and compliance with your research or quality control protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D7)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.