Description

Nicotinic Acid-13C6 CAS NO 1189954-79-7 is a stable isotope-labeled analog of nicotinic acid (Vitamin B3), where six carbon atoms are replaced with the carbon-13 isotope. This high-purity compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy in analytical measurements. It is critically needed by pharmaceutical R&D laboratories, clinical research facilities, and advanced metabolic studies for precise drug metabolism and pharmacokinetic (DMPK) analysis.

Application

• Quantitative Mass Spectrometry (LC-MS/MS, GC-MS): Serves as a critical internal standard for the accurate quantification of nicotinic acid and its metabolites in complex biological matrices.
• Pharmaceutical Drug Development: Used in DMPK studies to track the absorption, distribution, metabolism, and excretion of drug candidates and nutrients.
• Clinical Research & Diagnostics: Enables precise measurement of Vitamin B3 levels in plasma, serum, and tissues for nutritional status assessment and metabolic disorder research.
• Metabolomics & Biomarker Discovery: Facilitates high-fidelity profiling of metabolic pathways involving NAD+ biosynthesis and tryptophan metabolism.
• Stable Isotope Tracer Studies: Acts as a tracer to investigate the flux through metabolic networks in cell culture, animal models, and human subjects.
• Quality Control & Method Validation: Employed in analytical method development and validation to ensure compliance with regulatory guidelines (FDA, EMA) for bioanalytical assays.

Basic Information

Product Name	Nicotinic Acid-13C6
CAS No.	1189954-79-7
Molecular Formula	13C6H5NO2
Molecular Weight	129.05 g/mol (approx.)
Synonyms	Pyridine-3-carboxylic acid-13C6; Vitamin B3-13C6; Niacin-13C6; 3-Carboxypyridine-13C6; Nicotinate-13C6; Antipellagra vitamin-13C6; Pellagra preventive factor-13C6; PP factor-13C6
EINECS	Contact for details

Quality Control

Every batch of Nicotinic Acid-13C6 is manufactured and tested under strict quality management systems. We guarantee high chemical purity and isotopic enrichment, supported by comprehensive analytical data including NMR, HPLC, and mass spectrometry. Certificates of Analysis (COA) detailing purity, isotopic abundance, and all critical specifications are provided with each shipment to ensure compliance with research and regulatory standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98% (chemical purity)
Isotopic Enrichment	≥99 atom % 13C
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.