Description

Guanfacine is a highly selective α-2A adrenergic receptor agonist, a key active pharmaceutical ingredient (API) with significant therapeutic importance. Its primary value lies in its central nervous system activity, making it a critical component in the formulation of modern medications. This compound is essential for pharmaceutical manufacturers and research institutions developing treatments for conditions such as attention deficit hyperactivity disorder (ADHD) and hypertension.

Application

• Pharmaceutical API: Primary use as the active ingredient in prescription medications for the treatment of Attention Deficit Hyperactivity Disorder (ADHD).
• Hypertension Treatment: Used in the formulation of antihypertensive drugs due to its central α-adrenergic agonist activity.
• Neurological Research: A vital tool compound in preclinical and clinical research studying α-2 adrenoceptor pathways and central nervous system modulation.
• Generic Drug Manufacturing: Sourcing for the production of cost-effective generic versions of branded guanfacine medications.
• Controlled-Release Formulations: Used in the development of extended-release tablet formulations to provide steady plasma concentration.
• Reference Standard: Serves as a high-purity analytical standard for quality control testing in pharmaceutical laboratories.

Basic Information

Product Name	Guanfacine
CAS No.	1189924-28-4
Molecular Formula	C9H9Cl2N3O
Molecular Weight	246.09 g/mol
Synonyms	Guanfacine Hydrochloride (common salt form); (2,6-Dichlorophenyl)acetyl]guanidine; Estulic; Tenex; Intuniv; 1-(2,6-Dichlorophenyl)acetyl]guanidine; N-Amidino-2-(2,6-dichlorophenyl)acetamide; BRN 2809266
EINECS	Contact for details

Quality Control

Our Guanfacine is manufactured under strict quality management systems, targeting standards suitable for pharmaceutical applications. Each batch undergoes comprehensive analytical testing including identification, assay, impurity profiling, and residual solvent analysis to ensure it meets stringent purity requirements. A Certificate of Analysis (COA) documenting all test results is provided with every shipment, and we support customer audits and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 1.0%; Any individual impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.