Description

3,4-Dihydroxyphenylacetic Acid-13C,18O2 is a stable isotope-labeled analog of the endogenous metabolite 3,4-Dihydroxyphenylacetic acid (DOPAC). This compound is essential for advanced analytical research, providing an internal standard for precise quantification in mass spectrometry. It is primarily used by researchers and quality control laboratories in the pharmaceutical, biotechnology, and clinical diagnostics sectors for metabolic pathway studies and biomarker analysis.

Application

• Internal Standard for LC-MS/MS: Critical for the accurate quantification of endogenous DOPAC in complex biological matrices like plasma, urine, and cerebrospinal fluid.
• Metabolomics Research: Used as a tracer to study dopamine metabolism and related neurological pathways in preclinical and clinical research.
• Biomarker Assay Development: Enables the development and validation of high-sensitivity diagnostic assays for neurological and endocrine disorders.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Facilitates precise measurement of drug effects on catecholamine turnover in drug discovery and development.
• Quality Control in Pharmaceutical Manufacturing: Serves as a reference standard in the QC of pharmaceuticals targeting the central nervous system.

Basic Information

Product Name	3,4-Dihydroxyphenylacetic Acid-13C,18O2
CAS No.	1189915-73-8
Molecular Formula	C713C1H8O418O22
Molecular Weight	~172.13 g/mol (labeled)
Synonyms	DOPAC-13C,18O2; 3,4-Dihydroxybenzeneacetic-13C,18O2 Acid; (3,4-Dihydroxyphenyl)acetic-13C,18O2 Acid; 2-(3,4-Dihydroxyphenyl)acetic-13C,18O2 Acid; 3,4-DHPA-13C,18O2; Homoprotocatechuic-13C,18O2 Acid; Isotopically Labeled DOPAC; [13C,18O2]-DOPAC
EINECS	Contact for details

Quality Control

Our 3,4-Dihydroxyphenylacetic Acid-13C,18O2 is manufactured under strict quality systems to ensure the highest isotopic and chemical purity for critical research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (e.g., 13C, 18O), chemical purity by HPLC, and identity confirmation by NMR and MS. We adhere to relevant standards for high-purity reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This product is easily oxidized (store under inert atmosphere) and is light-sensitive (store away from light). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Enrichment (13C)	≥99 atom %
Isotopic Enrichment (18O)	≥95 atom % (per labeled oxygen)
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.