Description

Carbamazepine-D2 (Major) is a deuterated analog of the widely used anticonvulsant and mood-stabilizing drug, carbamazepine, specifically labeled at a major metabolic site. This stable isotope-labeled compound is an essential internal standard for accurate quantitative analysis in bioanalytical and pharmacokinetic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in method development, drug metabolism research, and therapeutic drug monitoring.

Application

• Bioanalytical Method Development: Serves as a critical internal standard in LC-MS/MS and GC-MS assays for quantifying carbamazepine and its metabolites in biological matrices like plasma, serum, and urine.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables precise and reliable measurement of drug concentration-time profiles in clinical and non-clinical research.
• Drug Metabolism and Disposition (DMPK): Used in mass spectrometry-based studies to investigate metabolic pathways, bioavailability, and clearance of carbamazepine.
• Therapeutic Drug Monitoring (TDM): Facilitates accurate assay calibration for monitoring patient drug levels to ensure efficacy and avoid toxicity.
• Forensic and Toxicology Analysis: Employed as a reference standard in confirmatory testing for carbamazepine in forensic and clinical toxicology laboratories.
• Impurity Profiling and Reference Standard: Acts as a certified reference material for identifying and quantifying related substances in drug substance and product quality control.

Basic Information

Product Name	Carbamazepine-D2 (Major)
CAS No.	1189902-21-3
Molecular Formula	C15H10D2N2O
Molecular Weight	238.29 g/mol
Synonyms	5H-Dibenzo[b,f]azepine-5-carboxamide-10,11-dideutero; Deuterated Carbamazepine (10,11-D2); Carbamazepine-d2; 10,11-Dideuterocarbamazepine; 5-Carbamoyl-5H-dibenzo[b,f]azepine-10,11-d2; Tegretol-d2 (labeled analog); CBZ-d2; G 32883-d2
EINECS	Contact for details

Quality Control

Our Carbamazepine-D2 (Major) is manufactured under strict quality control protocols to ensure high chemical and isotopic purity suitable for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, MS, and HPLC. A comprehensive Certificate of Analysis (COA) detailing assay, isotopic enrichment, chemical purity, and solvent residues is provided to guarantee traceability and consistency for your research and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. The product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0% (chemical purity)
Isotopic Purity (D2)	≥98.0 atom % D
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.