Description

Telmisartan-D3 CAS NO 1189889-44-8 is a deuterium-labeled analog of the angiotensin II receptor blocker (ARB) Telmisartan, specifically designed for use as an internal standard in quantitative bioanalytical methods. This stable isotope-labeled compound is essential for ensuring the accuracy and precision of pharmacokinetic and metabolic studies, eliminating variability from matrix effects and instrument drift. It is a critical tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and regulatory bodies involved in drug development and bioequivalence testing for cardiovascular therapeutics.

Application

• Quantitative Bioanalysis: Serves as a stable isotope internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) for the precise quantification of Telmisartan in biological matrices (plasma, serum, urine).
• Pharmacokinetic (PK) Studies: Enables accurate measurement of drug absorption, distribution, metabolism, and excretion (ADME) profiles in clinical and pre-clinical trials.
• Metabolite Profiling: Used in mass spectrometry to differentiate drug-derived metabolites from endogenous compounds, aiding in metabolic pathway identification.
• Method Development & Validation: Critical for developing and validating robust, GLP-compliant analytical methods for regulatory submissions to agencies like the FDA and EMA.
• Drug Impurity & Degradation Studies: Can be utilized as a reference to study and quantify potential impurities or degradation products in pharmaceutical formulations.
• Doping Control Analysis: Applied in sports anti-doping laboratories for the definitive identification and quantification of Telmisartan and related substances.

Basic Information

Product Name	Telmisartan-D3
CAS No.	1189889-44-8
Molecular Formula	C33H27D3N4O2
Molecular Weight	517.62 g/mol
Synonyms	4'-[(1,7'-Dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl]-[1,1'-biphenyl]-2-carboxylic Acid-d3; Telmisartan (methyl-d3); Telmisartan-d3 (methyl-d3); 2-(4-{[4-Methyl-6-(1-methyl-1H-1,3-benzodiazol-2-yl)-2-propyl-1H-1,3-benzodiazol-1-yl]methyl}phenyl)benzoic Acid-d3; BIBR 277-d3; Pritor-d3; Micardis-d3; Deuterated Telmisartan.
EINECS	Contact for details

Quality Control

Our Telmisartan-D3 is manufactured under strict quality control protocols to ensure the high chemical purity and isotopic enrichment required for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and MS, to confirm identity, purity, and deuterium incorporation. Certificates of Analysis (COA) detailing batch-specific results for assay, isotopic purity, and chemical purity are provided and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (deuterium incorporation)	≥ 99.0 atom % D
Chemical Purity (by NMR)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.