Description

4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol-1,2',3',4',5',6'-13C6 is a stable isotope-labeled analog of the tobacco-specific nitrosamine metabolite NNAL, essential for precise quantitative analysis in research. This compound is a critical internal standard for mass spectrometry, enabling accurate biomonitoring and pharmacokinetic studies of tobacco carcinogen exposure. It is primarily required by analytical laboratories, contract research organizations (CROs), and academic institutions conducting advanced toxicology and cancer research.

Application

• Internal Standard for LC-MS/MS: Used as a quantitative reference standard for the accurate measurement of NNAL in complex biological matrices like urine, serum, and plasma.
• Biomarker Research: Facilitates studies on tobacco smoke exposure, carcinogen metabolism, and associated cancer risk assessment in epidemiological and clinical research.
• Pharmacokinetic & Metabolic Studies: Enables precise tracking of the absorption, distribution, metabolism, and excretion (ADME) of tobacco-specific nitrosamines.
• Method Development & Validation: Critical for developing and validating highly sensitive and specific analytical methods in regulatory and forensic toxicology.
• Quality Control in Clinical Testing: Ensures accuracy and reliability in commercial diagnostic assays designed to measure tobacco carcinogen exposure.

Basic Information

Product Name	4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol-1,2',3',4',5',6'-13C6
CAS No.	1189877-28-8
Molecular Formula	C913C6H13N3O2
Molecular Weight	~213.2 (based on 13C6 labeling)
Synonyms	NNAL-13C6; 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol-13C6; (S)-NNAL-13C6; 4-(N-Methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanol-1,2',3',4',5',6'-13C6; 4-(Methylnitrosamino)-1-(3-pyridinyl)-1-butanol-13C6; NNAL Stable Isotope Labeled Standard
EINECS	Contact for details

Quality Control

Our stable isotope-labeled standards are manufactured under strict quality systems to ensure the highest isotopic and chemical purity for critical research applications. Each batch is characterized by advanced analytical techniques including NMR and high-resolution mass spectrometry to confirm isotopic enrichment and structural integrity. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), isotopic purity, and spectroscopic data is provided with every shipment to support your method validation and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or solution (as specified)
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98% (Chemical Purity)
Isotopic Purity	≥99 atom % 13C
Isotopic Enrichment	≥98% (at six labeled positions)
Solvent (if supplied as solution)	Methanol, Acetonitrile, or as specified
Concentration (if supplied as solution)	100 µg/mL ± 10% (or as specified)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.