Description

Zolpidem-D6 Phenyl-4-Carboxylic Acid is a stable isotope-labeled derivative of a key intermediate in the synthesis of the sedative-hypnotic drug Zolpidem. This compound is essential for the development and validation of highly sensitive and accurate analytical methods, particularly in pharmacokinetic and metabolic studies. It is primarily used by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities specializing in bioanalytical method development and forensic toxicology.

Application

• Internal Standard for LC-MS/MS Analysis: Serves as a critical internal standard for the precise quantification of Zolpidem and its metabolites in biological matrices like plasma, serum, and urine.
• Pharmaceutical Research & Development: Used in drug metabolism and pharmacokinetics (DMPK) studies to track the absorption, distribution, metabolism, and excretion (ADME) profile of Zolpidem.
• Forensic and Clinical Toxicology: Enables accurate detection and measurement of Zolpidem in forensic investigations and clinical overdose cases, ensuring reliable legal and medical outcomes.
• Bioanalytical Method Development: Aids in the development, validation, and quality control of robust HPLC and mass spectrometry-based assays for regulatory submissions.
• Reference Standard for Impurity Profiling: Acts as a certified reference material (CRM) for identifying and quantifying synthetic impurities or degradation products in Zolpidem active pharmaceutical ingredient (API) batches.
• Metabolite Synthesis and Identification: Used as a precursor or reference compound in the synthesis and structural elucidation of deuterated Zolpidem metabolites.

Basic Information

Product Name	Zolpidem-D6 Phenyl-4-Carboxylic Acid
CAS No.	1189868-12-9
Molecular Formula	C19H15D6N3O3
Molecular Weight	333.40 g/mol (for deuterated form)
Synonyms	2-(4-Methylphenyl)-N,N,6-trimethyl-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine-5-carboxamide-D6; 4-Methyl-2-(6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl)pyrimidine-5-carboxylic Acid-D6; Zolpidem Carboxylic Acid-D6; Zolpidem Impurity F-D6; Zolpidem Related Compound F-D6; Deuterated Zolpidem Acid; [D6]-Zolpidem Phenylcarboxylic Acid
EINECS	Contact for details

Quality Control

Every batch of Zolpidem-D6 Phenyl-4-Carboxylic Acid is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity to meet the exacting standards of analytical and research applications. Comprehensive testing includes identity confirmation by spectroscopic methods (NMR, IR, MS), purity assessment by HPLC, and verification of deuterium incorporation. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content, MS)	≥ 98.0 atom % D
Chemical Purity (Titration)	≥ 97.0%
Residual Solvents (GC)	Complies with ICH limits
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.