Description

1,2-Hydrazinedicarboxamide-13C2,15N2 is a stable isotope-labeled analog of oxamic hydrazide, where two carbon atoms and two nitrogen atoms are replaced with the 13C and 15N isotopes, respectively. This compound is a critical internal standard and tracer in advanced analytical chemistry, enabling precise quantification and metabolic pathway elucidation. It is primarily required by pharmaceutical research organizations, contract research laboratories, and agrochemical developers for use in mass spectrometry-based methods like LC-MS/MS and GC-MS.

Application

• Internal Standard for Quantitative Bioanalysis: Essential for accurate quantification of oxamic acid derivatives or related metabolites in complex biological matrices (plasma, urine, tissue) using LC-MS/MS.
• Metabolic Pathway Tracing: Used as a stable isotope tracer in drug metabolism and pharmacokinetics (DMPK) studies to track the fate of the oxamoyl moiety.
• Proteomics & Biochemical Research: Serves as a reagent or building block in the synthesis of isotopically labeled peptides or enzyme inhibitors for mechanistic studies.
• Environmental Fate Studies: Applied in agrochemical research to trace the degradation and environmental transformation pathways of related compounds.
• NMR Spectroscopy: Utilized as a probe in nuclear magnetic resonance spectroscopy due to its distinct isotopic signature, aiding in structural analysis.
• Reference Material for Regulatory Submissions: Provides the definitive standard required for method validation and compliance with FDA, EMA, and other regulatory guidelines for new drug applications.

Basic Information

Product Name	1,2-Hydrazinedicarboxamide-13C2,15N2
CAS No.	1189730-21-9
Molecular Formula	13C2H6N215N2O2
Molecular Weight	~122.06 g/mol
Synonyms	Oxamic Hydrazide-13C2,15N2; Oxalamide Hydrazone-13C2,15N2; Hydrazine-1,2-dicarboxamide-13C2,15N2; 1,2-Dicarbamoylhydrazine-13C2,15N2; [13C2,15N2]-Oxalamide hydrazone; Isotopically Labeled Oxamic Hydrazide; (13C2,15N2)-1,2-Hydrazinedicarboxamide
EINECS	Contact for details

Quality Control

Every batch of 1,2-Hydrazinedicarboxamide-13C2,15N2 is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive characterization via NMR, MS, and HPLC. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting the isotopic enrichment (atom % 13C and 15N), chemical purity, and results from all identity and purity tests, ensuring traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture uptake, which can affect stability and weighing accuracy. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (13C)	≥ 99 atom %
Isotopic Enrichment (15N)	≥ 99 atom %
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.