Description

Losartan-D3 Carboxylic Acid is a stable isotope-labeled analog of the Losartan metabolite, Losartan Carboxylic Acid, where three hydrogen atoms are replaced by deuterium. This compound is essential as a high-purity internal standard for the accurate quantification of Losartan and its active metabolite in biological matrices using Liquid Chromatography-Mass Spectrometry (LC-MS/MS). It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in bioanalytical method development, pharmacokinetic studies, and drug metabolism research.

Application

• Internal Standard for LC-MS/MS Analysis: Critical for the precise and reliable quantification of Losartan and its active metabolite in plasma, serum, and urine during bioanalytical studies.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in research to understand the absorption, distribution, metabolism, and excretion (ADME) profile of Losartan.
• Clinical Trial Support: Enables accurate therapeutic drug monitoring and pharmacokinetic profiling in human and animal clinical studies.
• Pharmaceutical Quality Control: Supports method development and validation for impurity profiling and stability testing of Losartan drug products.
• Forensic and Toxicological Analysis: Aids in the detection and quantification of Losartan in complex biological samples for forensic investigations.
• Reference Standard for Metabolite Synthesis: Serves as a key intermediate or reference material in the synthesis of other labeled metabolites or derivatives.

Basic Information

Product Name	Losartan-D3 Carboxylic Acid
CAS No.	1189729-40-5
Molecular Formula	C22H20D3ClN6O
Molecular Weight	425.94 g/mol
Synonyms	Losartan Carboxylic Acid-d3; 2-Butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic Acid-d3; EXP 3174-d3; E-3174-d3; Losartan Active Metabolite-d3; [2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]imidazole-5-carboxylic Acid]-d3
EINECS	Contact for details

Quality Control

Our Losartan-D3 Carboxylic Acid is manufactured under strict quality control protocols to ensure exceptional isotopic purity and chemical integrity, suitable for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for isotopic enrichment (D-content), chemical purity by HPLC, and identity confirmation. We support compliance with ICH Q2(R1) guidelines for analytical method validation.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, cool place. This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Chemical Purity (by HPLC)	≥ 95.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.