Description

1,7-Dimethyluric Acid-D3 is a stable isotope-labeled analog of a key purine metabolite, specifically deuterated at three positions. This compound is essential for precise quantitative analysis in mass spectrometry-based applications, where it serves as an internal standard to ensure accuracy and reproducibility. It is primarily required by researchers and quality control laboratories in the pharmaceutical, clinical diagnostics, and metabolomics fields for method development and validation.

Application

• Internal Standard for LC-MS/MS: Used for the accurate quantification of 1,7-dimethyluric acid and related xanthine metabolites in biological matrices like plasma, serum, and urine.
• Biomarker Research: Facilitates studies on caffeine metabolism, metabolic disorders, and liver function by providing a stable reference point in analytical assays.
• Clinical Diagnostics: Supports the development of robust diagnostic tests for monitoring drug metabolism and endogenous metabolic pathways.
• Pharmaceutical R&D: Employed in pharmacokinetic and pharmacodynamic studies to track the metabolism of drug candidates and dietary components.
• Metabolomics Profiling: A critical tool in high-throughput screening for identifying and quantifying purine-derived metabolites in complex samples.
• Reference Material: Serves as a certified reference material (CRM) for calibrating analytical instruments and validating laboratory methods.

Basic Information

Product Name	1,7-Dimethyluric Acid-D3
CAS No.	1189713-08-3
Molecular Formula	C7H5D3N4O3
Molecular Weight	199.18 g/mol
Synonyms	1,7-Dimethyluric-1,3,9-2H3 Acid; 1,7-Dimethyluric Acid (trideuterated); 1,7-Dimethyluric Acid-d3; 1,3,7-Trimethyluric Acid-d3 (isomer-specific); Deuterated 1,7-Dimethyluric Acid; 1,7-DMU-d3; 8-Oxo-1,7-dimethyl-3,7-dihydro-1H-purine-2,6-dione-d3; Stable Isotope-Labeled 1,7-Dimethyluric Acid
EINECS	Contact for details

Quality Control

Our 1,7-Dimethyluric Acid-D3 is manufactured under strict quality systems to ensure the high chemical purity and isotopic enrichment required for analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic purity (D-enrichment), chemical purity by HPLC, and identity confirmation. We adhere to relevant standards for high-purity reference materials to guarantee reliable and reproducible performance in your critical assays.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. Due to its hygroscopic nature, the material should be handled in a low-humidity atmosphere and the container kept sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D-enrichment)	≥98 atom % D
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.