Description

Vardenafil-D5 CAS NO 1189685-70-8 is a stable isotope-labeled analog of Vardenafil, where five hydrogen atoms are replaced by deuterium. This high-purity reference standard is critical for ensuring the accuracy and reliability of quantitative analytical methods. It is primarily used by pharmaceutical R&D laboratories, contract research organizations (CROs), and quality control departments for method development, validation, and pharmacokinetic studies.

Application

• Internal Standard for LC-MS/MS Analysis: Serves as a crucial internal standard for the precise quantification of Vardenafil and its metabolites in biological matrices (e.g., plasma, serum) during bioanalytical studies.
• Pharmaceutical Research & Development: Used in method development and validation for drug substance and drug product analysis, ensuring regulatory compliance for new drug applications (NDA).
• Pharmacokinetic and Metabolism Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles in clinical and pre-clinical trials.
• Quality Control and Assurance: Employed in pharmaceutical manufacturing for assay and impurity testing, guaranteeing batch-to-batch consistency and product purity.
• Forensic and Anti-Doping Analysis: Acts as a reference material in forensic toxicology and sports drug testing for the definitive identification and quantification of Vardenafil.

Basic Information

Product Name	Vardenafil-D5
CAS No.	1189685-70-8
Molecular Formula	C23H27D5N6O4S
Molecular Weight	492.62 g/mol
Synonyms	Vardenafil-d5; [2H5]-Vardenafil; 2-[2-ethoxy-5-[(4-ethylpiperazin-1-yl)sulfonyl]phenyl]-5-methyl-7-propyl-1H-imidazo[5,1-f][1,2,4]triazin-4(3H)-one-d5; Levitra-d5; Nuviva-d5; Staxyn-d5; Deuterated Vardenafil
EINECS	Contact for details

Quality Control

Our Vardenafil-D5 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR, HPLC, and MS, to confirm chemical identity, isotopic purity (≥98 atom % D), and chemical purity (typically ≥98%). Certificates of Analysis (COA) detailing all specifications and test results are provided and traceable to certified reference materials where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant use and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98 atom % D
Chemical Purity	≥ 98.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.