Description

Mesna-D4 (May Contain Up To 10% Disulfide) is a deuterated isotopologue of the pharmaceutical agent mesna, specifically designed for use as an internal standard in analytical chemistry. This compound is critical for ensuring the accuracy and reliability of quantitative analyses, particularly in pharmacokinetic and metabolic studies. It is an essential tool for researchers and quality control laboratories in the pharmaceutical, biotechnology, and contract research organization (CRO) sectors who require precise measurement of mesna and its metabolites.

Application

• Analytical Internal Standard: Primary use as a deuterated internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for the accurate quantification of mesna.
• Pharmaceutical Research & Development: Employed in method development and validation for bioanalytical assays during drug discovery and clinical trials.
• Metabolite Tracing: Used in metabolic stability studies and ADME (Absorption, Distribution, Metabolism, Excretion) profiling to track drug pathways.
• Pharmacokinetic (PK) Studies: Essential for generating reliable PK data by correcting for matrix effects and instrument variability in plasma, urine, and tissue sample analysis.
• Quality Control & Assurance: Applied in pharmaceutical manufacturing QC labs to monitor mesna levels in active pharmaceutical ingredients (APIs) and finished drug products.
• Forensic and Clinical Toxicology: Supports accurate quantification in specialized testing environments.

Basic Information

Product Name	Mesna-D4 (May Contain Up To 10% Disulfide)
CAS No.	1189479-73-9
Molecular Formula	C2H2D4NaO3S2
Molecular Weight	169.21 g/mol (for C2H2D4NaO3S2)
Synonyms	Sodium 2-mercaptoethanesulfonate-D4; Deuterated Mesna; Mesna-d4; Uromitexan-D4; Mistabron-D4; Sodium mercaptoethanesulphonate-D4; 2-Mercaptoethanesulfonic acid sodium salt-D4; Mesnum-D4
EINECS	Contact for details

Quality Control

Every batch of Mesna-D4 is produced and analyzed under strict quality management protocols. We provide comprehensive Certificates of Analysis (COA) that detail critical parameters including isotopic purity, chemical purity, and the disulfide content. Our quality systems are designed to meet the rigorous demands of analytical reference standard applications, ensuring traceability and reliability for your research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and easily oxidized; therefore, containers should be sealed under an inert atmosphere after opening and desiccants are recommended for long-term storage.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Mesna-D4)
Isotopic Purity (D-content)	≥ 98 atom % D
Disulfide Content (Mesna-D4 Disulfide)	≤ 10%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.