Description

4-[Bis(2-Hydroxypropyl)Amino]Benzoic Acid-D4 Ethyl Ester is a deuterated derivative of a key benzoic acid ester, serving as a critical stable isotope-labeled standard for analytical research. This compound is essential for ensuring the accuracy and reliability of quantitative mass spectrometry analyses, particularly in pharmacokinetic and metabolic studies. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in advanced analytical method development.

Application

• Internal Standard for LC-MS/MS: Used as a quantitative reference standard in bioanalytical assays for drug and metabolite quantification in biological matrices like plasma and urine.
• Metabolite Tracing: Employed in stable isotope labeling studies to track the metabolic fate and pathways of pharmaceutical compounds.
• Method Development & Validation: Critical for developing and validating sensitive and specific analytical methods in accordance with FDA and ICH guidelines.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of process-related impurities and degradation products in Active Pharmaceutical Ingredients (APIs).
• Doping Control Analysis: Can be utilized as a reference material in sports anti-doping laboratories for precise measurement of prohibited substances.
• Environmental Fate Studies: Applied in environmental science to study the degradation and transformation of chemical compounds using isotope dilution techniques.

Basic Information

Product Name	4-[Bis(2-Hydroxypropyl)Amino]Benzoic Acid-D4 Ethyl Ester
CAS No.	1189469-25-7
Molecular Formula	C16H21D4NO5
Molecular Weight	311.40 g/mol (for deuterated form)
Synonyms	Ethyl 4-[bis(2-hydroxypropyl)amino]benzoate-d4; Benzoic acid, 4-[bis(2-hydroxypropyl)amino]-, ethyl ester-d4; Deuteronated 4-[Bis(2-Hydroxypropyl)Amino]Benzoic Acid Ethyl Ester; 4-(Bis(2-hydroxypropyl)amino)benzoic acid ethyl-d4 ester; Stable Isotope Labeled Internal Standard 1189469-25-7; D4-labeled 4-(Bis(2-hydroxypropyl)amino)benzoic acid ethyl ester
EINECS	Contact for details

Quality Control

Every batch of 4-[Bis(2-Hydroxypropyl)Amino]Benzoic Acid-D4 Ethyl Ester is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity to meet the exacting demands of analytical reference standards. Comprehensive testing includes assay by HPLC, isotopic enrichment by MS, and control of related substances. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Assay (HPLC)	≥98.0% (chemical purity)
Isotopic Enrichment	≥98 atom % D
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤0.5% w/w
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.